Abstract:
This study focuses on developing and investigating innovative water-soluble
polymer systems based on sodium alginate for drug delivery, specifically for con
trolled lidocaine release. A novel hydrogel was formulated with a unique compo
sition, including sodium alginate, azithromycin, lidocaine, and levomenthol, among
other auxiliary components. These hydrogels exhibit a significant capacity for water
absorption, directly proportional to the sodium alginate concentration. Enhanced
moisture retention was observed, attributed to the proposed hydrogel composition
and its excipients. The hydrogels demonstrate non-Newtonian, pseudoplastic be
havior, with viscosity dependent on both sodium alginate concentration and tem
perature; an increase in temperature notably reduces hydrogel viscosity. Further
more, the research confirms the feasibility of controlled and prolonged drug release,
particularly for lidocaine, with approximately 60% of lidocaine released within
60 minutes and over 80% within 90 minutes. Ultimately, optimizing sodium alginate
concentration and controlling temperature allow for the targeted regulation of key
hydrogel properties, including water absorption, viscosity, and release kinetics.
These findings highlight the broad potential for applying sodium alginate-based hy
drogels in the pharmaceutical industry to create advanced controlled-release sys
tems, especially for lidocaine delivery
